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一抗
整合素样金属蛋白酶与凝血酶1型抗体
产品详细信息
产品货号：hj-1139A
英文：ADAMTS1
【友情提示】：
产品介绍background:
ADAMTS1 is a metalloproteinase of the ADAM (A Disintegrin And Metalloproteinase) family containing disintegrin-like domains. ADAMTS1, also known as METH1, was first described as a protein elevated in invasive mouse tumors. Initial findings indicated a role for ADAMTS1 in tumor progression, since the protein was preferentially expressed in more invasive tumor cell lines. ADAMTS1 is necessary for normal growth, fertility, and organ morphology and function.
Function:
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.
Subcellular Location:
Secreted > extracellular space > extracellular matrix.
Post-translational modifications:
The precursor is cleaved by a furin endopeptidase.
Similarity:
Contains 1 disintegrin domain.
Contains 1 peptidase M12B domain.
Contains 3 TSP type-1 domains.